Aminoglycosides Pharmacokinetics

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To calculate creatinine clearance, you must enter age, height, weight, and gender in the Patient Parameters section and serum creatinine in Creatinine Clearance section. You can use the Birthdate field to auto calculate the age.
Adjusted weight is used if actual weight is greater than 120% of ideal body weight.
For patient age 65 years or older, the serum creatinine will be rounded to 1.0 if it is less than 1.0.
If you want to use your own clearance value (such as when calculated clearance is greater than 120 mL/min, you can enter a value in User-defined Cl and this value will be used for calculations. The Calculation Cl displays the clearance that will be used for calculations.
Note: Cockroft-Gault equation is used to estimate clearance. For Jelliffe estimation, see Rx Calculator.

Always complete the Patient Parameters and Clearance sections for aminoglycosides calculations. The Dosing Regimen is a common section for prospective and actual calculations.
For prospective calculation, Dose, Dosing Interval, Infusion Time, and V_d factor are required in the Dosing Regimen section. The results are displayed in the Prospective Calculation section after the V_d factor is entered or changed.
Note that some fields, such as dose, dosing interval, etc., are filled with default values in Dosing Regimen section. These can be changed to reflect your patient's values.

Always complete the Patient Parameters and Clearance sections for aminoglycosides calculations. The Dosing Regimen is a common section for prospective and actual calculations.
For actual calculation, all fields in Dosing Regimen section need to be filled or modified to reflect your patient's values. The results are displayed in the Actual Calculation section after the actual peak and trough are entered or changed.
Once you enter the peak and trough and true k_e and V_d are calculated, you can search for an optimal dose in the Dose Optimization sub-section in Actual Calculation section.
Note that some fields, such as dose, dosing interval, etc., are filled with default values in Dosing Regimen section. These can be changed to reflect your patient's values.

The ideal weight is calculated using the formula 50 + 2.3×(inches over 60) for men and 45 + 2.3×(inches over 60) for women. The adjusted weight is calculated only if actual weight is greater than 120% ideal body weight using the formula: adjusted = ideal + 0.4×(actual - ideal). Of the three weights (actual, ideal, or adjusted), the Calc weight displays the weight that will be used for calculating clearance.